## Data Analysis for Three Kinds of Hybrid Experimental Designs

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The Substance Abuse Research Assistance (SARA) Micro-Randomized Trial: Workflow and templates for reproducing results.

A clustered SMART is a type of randomized trial where intact clusters of units (e.g., patients) are randomized sequentially, yet the primary outcome is at the level of the units within the cluster. This software bundle does two things: (i) It provides data analysis code for comparing the embedded adaptive interventions in a clustered SMART on an end of study, continuous outcome. (ii) It provides the code for calculating the minimum sample size necessary for a clustered SMART in which the primary aim is the comparison of two adaptive interventions beginning with different interventions.

- Estimate the proximal and distal causal effects of a just-in-time intervention component on a continuous outcome using data from a Micro Randomized Trial Gallery
#### Estimate the proximal and distal causal effects of a just-in-time intervention component on a continuous outcome using data from a Micro Randomized Trial

This code is used to estimate the causal effect of a just-in-time intervention component on the mean of a continuous proximal or distal outcome using data from an MRT.

This code is used to investigate whether (and, if so, how) a baseline or time-varying covariate can be a useful tailoring variables in an adaptive intervention.

This code is used to estimate and compare change in the log-odds of success in a binary longitudinal outcome for the adaptive interventions embedded in a SMART.

This code is used to estimate and compare the mean change in a longitudinal outcome for the adaptive interventions embedded in a SMART using a marginal linear mixed modeling approach.

This code is used to estimate and compare the mean change in a longitudinal outcome for the adaptive interventions embedded in a SMART.

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