Frequently Asked Questions

Frequently Asked Questions

Explore our Frequently Asked Questions below, and make sure to join the d3center mailing list to stay up-to-date with the latest news, events, software releases, learning modules, and other resources.

Explore our Frequently Asked Questions below, and make sure to join the d3center mailing list to stay up-to-date with the latest news, events, software releases, learning modules, and other resources.

Home / Frequently Asked Questions

Home / Frequently Asked Questions

What does it mean for an adaptive intervention to be “embedded” in a SMART?

Can a SMART include just one randomization stage?

Should I consider a SMART if my goal is to evaluate the effectiveness of an already developed adaptive intervention?

Must I use a SMART to develop an optimized adaptive intervention?

Are SMARTs factorial designs?

What is an “embedded tailoring variable”?

Is it a requirement that all SMARTs include an embedded tailoring variable?

Is a SMART an adaptive trial design?

Do all aspects of an adaptive intervention have to be randomized/studied in a SMART?

When should I use a SMART design?

When should I conduct a Pilot SMART?

Is it difficult to calculate the sample size for a SMART?

Is it the case that SMARTs never include a reference group or “usual care treatment”?

At what stage would you run a SMART optimization study versus a confirmatory RCT?

Must an adaptive intervention recommend a single intervention component at each decision point?

Is it the case that Adaptive Interventions seek to replace clinical judgment?

You state that adaptive interventions are protocolized, but then you stated that clinical judgment can be part of an adaptive intervention. How can this be?

Can an adaptive intervention tailor the intervention at baseline?

In an adaptive intervention, can the tailoring variable differ depending on which intervention was provided in a previous stage?

Is randomization part of an adaptive intervention?

What is the difference between a SMART and an adaptive intervention?

What happens if the tailoring variable that is needed to inform the next intervention could not be collected, or its value is missing, for a specific patient?

The statistician on our research team has explained that missing data is best handled using a “multiple imputation” approach.

How do I address non-adherence in the design of an adaptive intervention?

Within an adaptive intervention, do the intervention options at any given decision point need to be similar in their dosage (i.e., frequency, duration, or intensity)?

FAQs – Search & Filter

FAQ Text Search
FAQs - Search by Category

Share This Page

FAQs – Search & Filter

FAQ Text Search
FAQs - Search by Category

What does it mean for an adaptive intervention to be “embedded” in a SMART?

Can a SMART include just one randomization stage?

Should I consider a SMART if my goal is to evaluate the effectiveness of an already developed adaptive intervention?

Must I use a SMART to develop an optimized adaptive intervention?

Are SMARTs factorial designs?

What is an “embedded tailoring variable”?

Is it a requirement that all SMARTs include an embedded tailoring variable?

Is a SMART an adaptive trial design?

Do all aspects of an adaptive intervention have to be randomized/studied in a SMART?

When should I use a SMART design?

When should I conduct a Pilot SMART?

Is it difficult to calculate the sample size for a SMART?

Is it the case that SMARTs never include a reference group or “usual care treatment”?

At what stage would you run a SMART optimization study versus a confirmatory RCT?

Must an adaptive intervention recommend a single intervention component at each decision point?

Is it the case that Adaptive Interventions seek to replace clinical judgment?

You state that adaptive interventions are protocolized, but then you stated that clinical judgment can be part of an adaptive intervention. How can this be?

Can an adaptive intervention tailor the intervention at baseline?

In an adaptive intervention, can the tailoring variable differ depending on which intervention was provided in a previous stage?

Is randomization part of an adaptive intervention?

What is the difference between a SMART and an adaptive intervention?

What happens if the tailoring variable that is needed to inform the next intervention could not be collected, or its value is missing, for a specific patient?

The statistician on our research team has explained that missing data is best handled using a “multiple imputation” approach.

How do I address non-adherence in the design of an adaptive intervention?

Within an adaptive intervention, do the intervention options at any given decision point need to be similar in their dosage (i.e., frequency, duration, or intensity)?

Events

View All Events

Join the d3center Mailing List

Keep up to date with the latest news, events, software releases, learning modules, and resources from the d3center.