Question

What does it mean for an adaptive intervention to be “embedded” in a SMART?

Answer

Researchers use Sequential, Multiple Assignment, Randomized Trial (SMART) designs to investigate the effectiveness of intervention components (or combinations of them) at multiple stages. At the beginning of each stage, participants may be assigned their next intervention through randomization (e.g., 50% receive treatment A, 50% receive treatment B). But, depending on the SMART, not all patients are randomized to a new intervention at every stage. In some SMARTs, only some participants (e.g., those most likely to benefit from additional intervention) are re-randomized. For example, in the SMART shown below, only those who did not respond to their assigned first-stage treatment are randomized to intervention D or intervention E.

In a SMART with this design, participants follow different treatment pathways determined by randomization and their response status. Each pair of pathways defines an adaptive intervention (above). For example, pathway A-C (available only to responders) combined with pathway A-D (available only to non-responders) represents one adaptive intervention (AI1). Pathway A-C combined with pathway A-E represents another adaptive intervention (AI2). We call these AIs “embedded” because their designs are readily apparent in the design of the SMART.

A common primary aim in a SMART is to compare the relative effectiveness of these embedded adaptive interventions. Our collection of downloadable and free-to-use software includes programs for conducting this type of analysis with data arising from a SMART.

Frequently Asked Questions

d3 Academy

Share This Page

Upcoming Events

View All Events
Presentation

Introduction to MAISYs

Prevention Science and Methodology Group Virtual Grand Rounds
January 24, 2023
Presentation

Introduction to MAISYs

University of Florida Health Outcomes and Biomedical Informatics Grand Rounds
February 13, 2023
Training Institute

Getting SMART

Comprehensive Program for Adaptive Interventions Training in Education (CATIE)
March 14, 2023
View All Events

LET’S STAY IN TOUCH

Join the d3center Mailing List

Keep up to date with the latest news, events, software releases, learning modules, and resources from the d3center.