Frequently Asked Questions – SMARTs

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What does it mean for an adaptive intervention to be “embedded” in a SMART?

Can a SMART include just one randomization stage?

Should I consider a SMART if my goal is to evaluate the effectiveness of an already developed adaptive intervention?

Must I use a SMART to develop an optimized adaptive intervention?

Are SMARTs factorial designs?

What is an “embedded tailoring variable”?

Is it a requirement that all SMARTs include an embedded tailoring variable?

Is a SMART an adaptive trial design?

Do all aspects of an adaptive intervention have to be randomized/studied in a SMART?

When should I use a SMART design?

When should I conduct a Pilot SMART?

Is it difficult to calculate the sample size for a SMART?

Is it the case that SMARTs never include a reference group or “usual care treatment”?

At what stage would you run a SMART optimization study versus a confirmatory RCT?

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