Frequently Asked Questions – Adaptive Interventions

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Must an adaptive intervention recommend a single intervention component at each decision point?

Is it the case that Adaptive Interventions seek to replace clinical judgment?

You state that adaptive interventions are protocolized, but then you stated that clinical judgment can be part of an adaptive intervention. How can this be?

Can an adaptive intervention tailor the intervention at baseline?

In an adaptive intervention, can the tailoring variable differ depending on which intervention was provided in a previous stage?

Is randomization part of an adaptive intervention?

What is the difference between a SMART and an adaptive intervention?

What happens if the tailoring variable that is needed to inform the next intervention could not be collected, or its value is missing, for a specific patient?

The statistician on our research team has explained that missing data is best handled using a “multiple imputation” approach.

How do I address non-adherence in the design of an adaptive intervention?

Within an adaptive intervention, do the intervention options at any given decision point need to be similar in their dosage (i.e., frequency, duration, or intensity)?

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