Is a SMART an adaptive trial design?


The SMART is not an adaptive trial design. In an adaptive trial design, the trial itself changes over time (i.e., is adapted) based on interim data. For example, accumulating study data may suggest the opportunity/need to change the study’s total sample size. Or, as a second example, interim study data may suggest that one of the treatments is clearly superior to the other, and the study can be terminated ahead of schedule.

SMARTs, on the other hand, are designed to inform the development of an adaptive intervention. For example, the set of available intervention options at each decision point in a SMART will typically remain the same from the beginning to the end of the trial.

Upcoming Events

Hybrid Experimental Designs for Developing Mobile Interventions

July 6, 2023
Leibniz Institute for Research and Information in Education
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Optimization of Adaptive Interventions

July 15, 2023, 10:45 - 12:00 p.m.
NIH Summer Institute on Randomized Behavioral Clinical Trials
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Leveraging digital technology to improve employee health and well-being: New intervention and experimental approaches

August 15, 2023
Disney Data and Analytics Conference
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Advances in Adaptive Interventions to Improve Outcomes for Individuals with SUD and HIV

October 3, 2023
UCSF, Center for AIDS Prevention Studies
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Optimizing the Adaptation and Personalization of SUD Services

October 18, 2023, 1:00 - 2:30 p.m.
Addiction Health Services Research Conference 2023
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