About this code

This code enables a three-level marginal mean modeling and estimation approach for comparing adaptive interventions in a clustered SMART. The proposed method enables policy analysts to answer a wider array of scientific questions in the marginal comparison of clustered adaptive interventions. Further, relative to using an existing two-level method with a nested end-of-study outcome, the proposed method benefits from improved statistical efficiency.

Related References

Durham, G., Battalahalli, A., Kilbourne, A., Quanbeck, A., Pan, W., Lycurgus, T., & Almirall, D. (2025).
Multilevel primary aim analyses of clustered SMARTs: With applications in health policy. arXiv.
https://doi.org/10.48550/arXiv.2503.08987

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