Patients suffering from bipolar disorder are assigned to one of two mood stabilizers. A SMART design is used to determine the appropriate treatment for patients who develop depression.

This project aims to develop an adaptive intervention for persistent insomnia. Researchers are using a SMART design to determine the best sequencing of cognitive behavioral therapy and medication for persistent insomnia.

Adolescents suffering from depression begin treatment with interpersonal psychotherapy. This pilot project employs a SMART design to help establish treatment rules regarding when and in what way to intensify treatment.

For youth with OCD, the most common treatments are cognitive-behavioral therapy (CBT), pharmacological treatment, or both. Up to 30% of patients may not benefit from their initial treatments. Researchers will employ a SMART to determine the optimal treatment sequence for participants dependent on whether or not they respond to their initial treatment.

This project targets African American adolescents with obesity and their parents. SMARTs are used to develop an adaptive intervention that increases skills in changing dietary, exercise, and sedentary behaviors.

Naltrexone (NTX) is an opioid receptor antagonist used to prevent alcoholism relapse. This trial examines how to define “non-response” to treatment with NTX and what treatments are most effective for those who do or do not respond to the initial treatment.

A SMART design is being implemented to develop an adaptive intervention to increase treatment engagement and decrease cocaine use for patients who are cocaine dependent. The study also examines whether patient choice of care affects patient outcomes.

The aim of this SMART is to understand whether to begin with medication or behavioral therapy for children with ADHD, and whether to intensify or augment initial treatment for children who do not respond to treatment.

Researchers in this study are developing an adaptive treatment for adolescent marijuana users. They are studying the use and combination of several efficacious treatments, including behavioral therapy, contingency management, behavioral parent training, and working memory training via a SMART trial.

Studies show that the use of stimulants for the control of ADHD in youth leads to a reduction in height gain. This study uses a SMART design to examine the effectiveness of temporary breaks in medicinal treatments and caloric supplementation for the treatment of stimulant-induced weight and growth suppression.